대표연구성과

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연구실소개

Xanthorrhizol


1. 원료식물 및 물질구조









                     Curcuma xanthorrhiza                                  Xanthorrhizol


2. 대표 논문 및 연구결과 

      구강 미생물 항균 및 항 Biofilm 활성 

1) J.K. Hwang, J.S. Shim, N.I. Baek and Y.R. Pyun. 2000.
    Xanthorrhizol : an antibacterial agent from Curcuma xanthorrhiza against Streptococcus mutans.
    Planta Medica, 66(2), 196-197.

2) J.K. Hwang, J.S. Shim and Y.R. Pyun. 2000.
    Antibacterial activity of xanthorrhizol from Curcuma xanthorrhiza against oral pathogens.
    Fitoterapia. 71, 321-323.

3) Yaya Rukayadi, Jae-Kwan Hwang. 2005.
    In vitro activity of xanthorrhizol against Streptococcus mutans biofilms.  
    Letters in Applied Microbiology, 42(4), 400-    404.

4) Yaya Rukayadi, Jae-Kwan Hwang. 2006.
    Effect of coating the wells of a polystyrene microtiter plate with xanthorrhizol on the biofilm formation of           
    Streptococcus mutans. 
    J. Basic Microbiol., 46(5), 411-416. 

5) Jung-Eun Kim, Hee-Eun Kim, Jae-Kwan Hwang, Ho-Jeong Lee, Ho-Keun Kwon, and Baek-Il Kim. 2008. 
   Antibacterial Characteristics of Curcuma xanthorrhiza Extract on Streptococcus mutans Biofilm.
   The Journal of Microbiology., 228-332.

                                                                                         Planta  Medica, 66(2), 196-197 
 


 
      항진균(Anti-fungal) 활성

1) Yaya Rukayadi, Jae-Kwan Hwang. 2006.
    In vitro anticandidal activity of xanthorrhizol isolated from Curcuma xanthorrhiza Roxb.
    J. Antimicrob. lChemother, 57(6), 1231-1234.

2) Yaya Rukayadi, Jae-Kwan Hwang. 2006.
    In vitro anti-Malassezia activity of xanthorrhizol isolated from Curcuma xanthorrhiza Roxb.
    Letters in Applied Microbiology, 44, 126-130.

3) Yaya Rukayadi, Jae-Kwan Hwang. 2007.
    In vitro antimycotic activity of xanthorrhizol isolated from Curcuma xanthorrhiza Roxb. against opportunistic  
    filamentous fungi.
    Phytother. Res., 21(5), 434-438. 
 

















                                                     J. Antimicrob.l Chemother, 57(6), 1231-1234 (2006) 




      항염증 및 항암 활성

1) Lee, S.K., Hong, C.H., Huh, S.K., Kim, S.S., Oh, O.J., Min, H.Y., Park, K.K., Chung, W.Y. and Hwang, J.K. 2002.
    Suppressive effect of natural sesquiterpenoids on inducible cyclooxygenase (COX-2) and nitric oxide
    synthase (iNOS) activity in mouse macrophage cells.
    J. Environ. Pathol. Toxicol. Oncol., 21(2), 141-148.

2) Jae-Hee Park, Mi-Jeong Kim, Kwang-Kyun Park, Heui-Og Kim, Jae-Kwan Hwang Hwang and Won-Yoon
   Chung. 2003.
   Chemopreventive Effect of Xanthorrhizol from Curcuma xanthorrhiza. 
   J. Korean Assoc. Cancer Prev., 8(2), 91-97.

3) Choi. M.A., Kim, S.H., Chung, W.Y. Hwang, J.K. and Park, K.K. 2005.
    Xanthorrhizol, a natural sesquiterpenoid from Curcuma xanthorrhiza, has an anti-metastatic potential in
    experimental mouse lung metastasis model.
    Biochem. Biophys. Res. Commun., 326, 210-217.

4) Won Young Chung, Jae Hee Park, Mi Jeong Kim, Jae Kwan Hwang, Sang Kook Lee, Kwang Kyun Park. 2007.
    Xanthorrhizol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stage mouse
    skin carcinogenesis by blocking the expression of ornithine decarboxylase, cyclooxygenese-2, and inducible
    nitric oxide synthase through mitogen-activated protein kinases and/or the nuclear factor kB.
    Carcinogenesis, 28 (6), 1224-1231. 





















                                                                       
                                                                       Biochem. Biophys. Res. Commun., 326, 210-217 (2005) 
















       항암제 독성완화 작용

1) Seong Hwan Kim, Kyoung Ok Hong, Won-Yoon Chung, Jae-Kwan Hwang and Kwang-Kyun Park. 2004.
    Abrogation of cisplatin-induced hepatotoxity in mice by xanthorrhizol is related to its effect on transcription
    factors, NK-κB and AP-1.
    Toxicology and Applied Pharmacology, 196, 346-355.

2) Kim, S.H., Hong, K.O., Hwang, J.K. and Park, K.K. 2005.
    Xanthorrhizol has a potential to attenuate the high dose cisplatin-induced nephrotoxicity.
    Food and Chemical Toxicology, 43(1), 117-122.

3) Hong, K.O., Hwang, J.K., Park, K.K. and Kim, S.H. 2005.
    Phosphorylation of c-Jun N-terminal kinases (JNKs) is involved in the preventive effect of xahthorrhizol on
    cisplatin-induced hepatotoxity.
    Archives of Toxicology, 79: 231-235. 


      뇌보호 활성

1) Lim, Chol Seung; Jin, Da-Qing; Mok, Hyejung; Oh, Sang Jin; Lee, Jung Uk; Hwang, Jae Kwan; Ha, Ilho; Han,   
    Jung-Soo. 2005.
    Antioxidant and anti-inflammatory activities of xanthorrhizol in hippocampal neurons and primary cultured
    microglia.
    J. Neurosci. Res., 82:831-838. 














                                                                                                            J. Neuro. Sci. 82, 831-838 (2005)

       
     구강 항균 및 항염증 임상연구

1) 김백일, 김상년, 장석윤, 문교태, 김윤석, 황재관, 정승화, 김민영, 김해선, 권호근. 2005.
    Curcuma xanthorrhiza 추출물 및 함유치약의 구취억제 효과와 국강 유해균에 대한 선택적 항균 효과.
    대한구강보건학회지. 29(2), 222-237.

2) Curcuma xanthorrhiza oil 및 죽염배합세치제의 치은염 억제효과.
    대한구강보건학회지. 29(4), 451-462 (2005).

3) 천연추출물 Curcuma xanthorrhiza oil 함유 치약의 치태 및 치은염 억제효과.
    대한치주과학회지. 35(4), 1053-1071 (2005).

4) Curcuma xanthorrhiza oil이 함유된 구강분무액의 구취감소효과에 관한 임상적 연구.
    대한구강보건학회지. 30(1) 75- 2006 (2006)


3. Xanthorrhizol Research Group

   - 황재관 교수 (연세대학교 생명공학과 )
   - 박광균 교수 (연세대학교 치과대학 구강생물학 교실)
   - 정원윤 교수 (연세대학교 치과대학 구강생물학 교실)
   - 김백일 교수 (연세대학교 치과대학 예방치과학 교실)
   - 김종관 교수 (연세대학교 치과대학 치주과학 교실)
   - 한정수 교수 (건국대학교 생명과학부)
   - Dr. Yaya Rukayadi (연세대학교 생명공학과)

   - 반재구 박사 (한국생명공학연구원)
   - 김성한 박사 (한국화학연구원) 

  




















4. 산업화 기술개발 및 상품화

Panduratin A



1. 원료식물 및 물질구조








                       Kaempferia pandurata                                Panduratin A



2. 대표 논문 및 연구결과 

      구강 미생물 항균 활성

1) Hwang, J.K., Chung, J.Y., Baek, N.I. and Park, J.H. 2004.
    Isopanduratin A from Kaempferia pandurata as a active antibacterial agent against. cariogenic Streptococcus
    mutans.
    Int. J. Antimicrob. Agents, 23(4), 377-381.

2) Kyung-Min Park, Jeong Han Choo, Jong-Hee Sohn, Sun-Hee Lee and Jae-Kwan Hwang. 2005. 
   Antibacterial Activity of Panduratin A Isolated from Kaempferia pandurata against Porphyromonas gingivali.
   Food Sci. Biotechnol., 14(2), 286-289. 


      항염증 및 항암 활성

1) Jung-Mi Yun, Hoonjeong Kwon and Jae-Kwan Hwang. 2003.
    In vitro anti-inflammatory activity of panduratin A Isolated from Kaempferia pandurata in RAW 264.7
    macrophages. 
    Planta Medica, 69, 1102-1108.

2) Yun, J.M., Kwon, H.J., Mukthar, H. and Hwang, J.K. 2005.
    Induction of apoptosis by panduratin A isolated from Kaempferia pandurata in human colon cancer HT-29 cells.
    Planta Medica, 71, 1-7.

3) Sohn, J.H., Han K.L., Lee, S.H. and Hwang, J.K. 2005.
    Protective effects of panduratin A against oxidative damage of tert-butylhydroperoxide in human HepG2 cells.
    Biol. Pharm. Bull., 28(6), 1083-1086.

4) Jung-Mi Yun, Mee-Hyang Kweon, Hoonjeong Kwon, Jae-Kwan Hwang, and Hasan Mukhtar. 2006.
    Induction of apoptosis and cell cycle arrest by a chalcone panduratin A isolated from Kaempferia pandurata in  
    androgen-independent human prostate cancer cells PC3 and DU145.
    Carcinogenesis, 27(7), 1454-1464. 














                                      Planta Medica, 71, 1-7 (2005)                Carcinogenesis, 27(7), 1454-1464 (2006) 















      피부기능 

1) Ji-Hoon Yoon, Jae-Seok Shim, Yu-Mi Cho, Nam-In Baek, Chan-Woo Lee, Han-Sung Kim, Jae-Kwan Hwang.
    2007.
     Depigmentation of Melanocytes by Chalcone Compounds Isolated from Kaempferia pandurata Roxb.
     Biol. Pharm. Bull., 30(11), 2141-2145.

2) Jae-Seok Shim, Yi-Young Kwon, Jae-Kwan Hwang. 2008.
     The Effects of Panduratin A Isolated from Kaempferia pandurata Roxb. on the Expression of Matrix Metalloproteinase-1
     and Type-1 Procollagen in Human Skin Fibroblasts.
     Planta Medica., 74, 239-244.




Macelignan


1. 원료식물 및 물질구조








                          Myristica fragrans                                    Macelignan



2. 대표 논문 및 연구결과 

      대사활성 

1) Da-Qing Jin, Chol Seung Lim, Jae Kwan Hwang, Ilho Ha, Jung Soo Han. 2005.
    Anti-oxidant and anti-inflammatory activities of macelignan in murine hippocampal cell line and primary culture
    of rat microglia cells.
    Biochem. Biophys. Res. Commun., 331, 1264-1269.

2) J.Y. Chung, J.H. Choo, M.H. Lee, J.K. Hwang. 2005. 
    Anticariogenic activity of macelignan isolated from Myristica fragrans (nutmeg) against Streptococcus mutans.
    Phytomedicine, 13(4), 261-266.

3) Jong Hee Sohn, Kyu Lee Han, Jeong Han Choo, Jae-Kwan Hwang. 2007.
    Macelignan protects HepG2 cells against tert-butylhydroperoxide-induced oxidative damage.
    Biofactors, 29, 1-10.

4) Sohn, J.H., Han, K.L. Kim, J.H., Hwang, J.K. 2008.  
   Protective effects of macelignan on cisplatin-induced hepatotoxicity is associated with JNK activation.
   Biol. Pharm. Bull., 31(2), 273-277.

5) Kyu Lee Han, Joo Sun Choi, Jae Young Lee, Jihyun Song, Myeong Ho Jung, Jae-Kwan Hwang. 2007.
   Therapeutic potential of PPAR-α/γ dual agonist with alleviation of ER stress for the treatment of diabetes mellitus. 
    Diabetes, 57(3), 737-45.


      구강 미생물 항균작용

1) Yanti, Yaya Rukayadi, Kyu-Hoi Kim, Jae-Kwan Hwang. 2008.
    In vitro anti-biofilm activity of macelignan isolated from Myristica fragrans Houtt. against oral primary colonizer
    bacteria.
    Phytotherapy Research, 22(3) 308-312.


      피부 기능

1) Yumi Cho, Kyu-Hoi Kim, Jae-Seok Shim and Jae-Kwan Hwang. 2008.
    Inhibitory Effect of Macelignan Isolated from Myristica fragrans Houtt. on Melanin Biosynthesis.
    Biol. Pharm. Bull., in press.